Manchester United winger Ryan Giggs has recovered from a calf strain and could face Portsmouth in the FA Cup at Old Trafford on Saturday.
The club's longest-serving player has been forced to miss the last three matches because of the injury.
Manager Sir Alex Ferguson has a full strength squad to call on other than Gary Neville, Mikael Silvestre and goalkeeper Ben Foster, who are building up their fitness after long-term injuries.
Pedro Mendes returns to the Portsmouth squad after five weeks out following a minor ankle operation.
Jermain Defoe is cup-tied so Kanu will start up front as the lone striker as Harry Redknapp reverts to his trusted 4-5-1 formation that has served Pompey well on their travels this season.
John Utaka will be recalled after being dropped to the bench for last weekend's 3-1 thrashing at European rivals Everton.
Long-term absentee Linvoy Primus (knee) and striker David Nugent (groin) will not travel to Old Trafford.
Squads:
Man Utd: Van der Sar, Brown, Vidic, Ferdinand, Evra, Ronaldo, Carrick, Fletcher, Hargreaves, Nani, Rooney, Tevez, Scholes, Giggs, O'Shea, Saha, Kuszczak, Anderson, Park, Simpson, Pique.
Portsmouth: James, Ashdown, Johnson, Distin, Campbell, Hreidarsson, Lauren, Aubey, Diop, Diarra, Muntari, Utaka, Davis, Mendes, Hughes, Kanu, Baros